期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 71, 期 5, 页码 593-600出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glv063
关键词
Biogenesis; Electron transport chain; Fish oil; Sunflower oil; Virgin olive oil
资金
- I+D grants from the Spanish Ministry of Education and Science [AGL2008-01057]
- Autonomous Government of Andalusia [AGR832]
- FPU program from the Spanish Ministry of Education
An age-dependent model of the periodontium was reproduced to evaluate the effect of life-long feeding on a low coenzyme Q(10) dosage in n-6, n-3 polyunsaturated fatty acid or monounsaturated fatty acid-based diets on periodontal tissues of young and old rats. Results shown that exacerbated age-related alveolar bone loss previously associated to n-6 polyunsaturated fatty acid diet was attenuated by coenzyme Q(10). Gene expression analysis suggests that involved mechanisms might be related to a restored capacity of mitochondria to adapt to aging in gingival cells from rats fed on n-6 polyunsaturated fatty acid. In particular, this could be due to an age-related increase of the rate of mitochondrial biogenesis and a better oxidative and respiratory balance in these animals. From the nutritional and clinical point of view, it is noteworthy that supplementation with coenzyme Q(10) could counteract the negative effects of n-6 polyunsaturated fatty acid on alveolar bone loss (a major feature of periodontitis) associated to age.
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