期刊
GLIA
卷 62, 期 11, 页码 1780-1789出版社
WILEY
DOI: 10.1002/glia.22722
关键词
Astrocyte; ATP; Axon; Glutamate; Oligodendrocyte
资金
- BBSRC
- NIH
- MS Society of Canada
- Canadian Institutes for Health Research
- Canada Research Chairs
- Alberta Heritage Foundation for Medical Research
- CIBERNED
- MINECO
- Eranet-Neuron
- BBSRC [BB/J016969/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/J016969/1] Funding Source: researchfish
Ischemic pathologies of white matter (WM) include a large proportion of stroke and developmental lesions while multiple sclerosis (MS) is the archetype nonischemic pathology. Growing evidence suggests other important diseases including neurodegenerative and psychiatric disorders also involve a significant WM component. Axonal, oligodendroglial, and astroglial damage proceed via distinct mechanisms in ischemic WM and these mechanisms evolve dramatically with maturation. Axons may pass through four developmental stages where the pattern of membrane protein expression influences how the structure responds to ischemia; WM astrocytes pass through at least two and differ significantly in their ischemia tolerance from grey matter astrocytes; oligodendroglia pass through at least three, with the highly ischemia intolerant pre-oligodendrocyte (pre-Oli) stage linking the less sensitive precursor and mature phenotypes. Neurotransmitters play a central role in WM pathology at all ages. Glutamate excitotoxicity in WM has both necrotic and apoptotic components; the latter mediated by intracellular pathways which differ between receptor types. ATP excitotoxicity may be largely mediated by the P2X7 receptor and also has both necrotic and apoptotic components. Interplay between microglia and other cell types is a critical element in the injury process. A growing appreciation of the significance of WM injury for nonischemic neurological disorders is currently stimulating research into mechanisms; with curious similarities being found with those operating during ischemia. A good example is traumatic brain injury, where axonal pathology can proceed via almost identical pathways to those described during acute ischemia.
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