期刊
GLIA
卷 59, 期 11, 页码 1567-1578出版社
WILEY
DOI: 10.1002/glia.21226
关键词
glia; signaling; dendritic spine; glutamate transporter; plasticity; hippocampus
资金
- Canadian Institutes of Health Research
- Canada Research Chairs Program
- Canadian Foundation for Innovation
- National Institutes of Health
- Department of Defense
- California Tobacco Related Disease Research Program
Neuron-glia communication is essential for regulating the properties of synaptic connections in the brain. Astrocytes, in particular, play a critical and complex role in synapse development, maintenance, and plasticity. Likewise, neurons reciprocally influence astrocyte physiology. However, the molecular signaling events that enable astrocytes and neurons to effectively communicate with each other are only partially defined. Recent findings have revealed that Eph receptor tyrosine kinases and ephrins play an important role in contact-dependent neuron-glia communication at synapses. Upon binding, these two families of cell surface-associated proteins trigger bidirectional signaling events that regulate the structural and physiological properties of both neurons and astrocytes. This review will focus on the emerging role of Eph receptors and ephrins in neuron-astrocyte interaction at synapses and discuss implications for synaptic plasticity, behavior, and disease. (C) 2011 Wiley-Liss, Inc.
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