期刊
GLIA
卷 59, 期 8, 页码 1148-1154出版社
WILEY
DOI: 10.1002/glia.21185
关键词
glioma; cancer stem cell; therapy resistance
资金
- National Brain Tumor Society
- Goldhirsh Foundation
- NIH [NS054276, CA129958, CA116659, CA154130]
- National Research Service [NS058042]
- Damon Runyon Cancer Research Foundation
- American Brain Tumor Association
- Canadian Cancer Society Research Institute
- Canadian Institutes for Health Research
- Ontario Institute for Cancer Research
- Terry Fox Foundation
- Hospital for Sick Children Foundation
- Jessica's Footprint Foundation
- National Cancer Institute
- National Institutes of Neurological Disorders, and Stroke/National Institutes of Health
Neuro-oncology research has rediscovered a complexity of nervous system cancers through the incorporation of cellular heterogeneity into tumor models with cellular subsets displaying stem-cell characteristics. Self-renewing cancer stem cells (CSCs) can propagate tumors and yield nontumorigenic tumor bulk cells that display a more differentiated phenotype. The ability to prospectively isolate and interrogate CSCs is defining molecular mechanisms responsible for the tumor maintenance and growth. The clinical relevance of CSCs has been supported by their resistance to cytotoxic therapies and their promotion of tumor angiogenesis. Although the field of CSC biology is relatively young, continued elucidation of the features of these cells holds promise for the development of novel patient therapies. (C) 2011 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据