期刊
GLIA
卷 56, 期 14, 页码 1491-1497出版社
WILEY
DOI: 10.1002/glia.20753
关键词
neuregulim; Schwann cell; myelination
资金
- DFG (SFB 665 Developmental Disturbances of the Nervous System, and Research Center 'Molecular Physiology of the Brain')
- BMBF (HELMA)
- The National Multiple Sclerosis Foundation a lid the Hertie Foundation
Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed neuregulin, promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by this factor is thus clearly astounding. (c) 2008 Wiley-Liss, Inc.
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