期刊
JOURNAL OF VIROLOGY
卷 90, 期 6, 页码 3268-3273出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02481-15
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资金
- CEIRS [HHSN272201400008C]
- HHS \ National Institutes of Health (NIH) [AI109946]
- PATH
We assessed whether influenza virus hemagglutinin stalk-based immunity protects ferrets against aerosol-transmitted H1N1 influenza virus infection. Immunization of ferrets by a universal influenza virus vaccine strategy based on viral vectors expressing chimeric hemagglutinin constructs induced stalk-specific antibody responses. Stalk-immunized ferrets were cohoused with H1N1-infected ferrets under conditions that permitted virus transmission. Hemagglutinin stalk-immunized ferrets had lower viral titers and delayed or no virus replication at all following natural exposure to influenza virus.
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