Prebiotic synthesis and selection of macromolecules: Thermal cycling as a condition for synthesis and combinatorial selection

A model of prebiotic synthesis and selection of macromolecules describing the origin of informative biopolymers is proposed; thermal cycling is considered as a driving force of the synthesis and evolution of prebiotic polymer systems. Kinetic models of prebiotic evolution and models of kinetic selection of optimal macromolecule configurations are provided. The proposed mechanisms of selection and competition are largely based on supramolecular interactions among monomers and polymers, as well as on the resistance of macromolecules to hydrolysis. The conditions of the interdependent coexistence of the three prebiotic polymer worlds are analyzed.