期刊
GENOMICS
卷 104, 期 5, 页码 347-351出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2014.08.021
关键词
5-hydroxymethylcytosine; DNA demethylation; Brain; Development; Neurological disorders
资金
- National Natural Science Foundation of China [31371309]
- National Key Basic Research Program of China [2014CB943001]
- Fundamental Research Funds for the Central Universities [2014QNA6002]
Epigenetic modulations play essential roles in diverse biological processes. During the past several years, DNA demethylation has been discovered in embryonic and postnatal development. Although some potential functions of DNA methylation have been demonstrated already, many questions remain in terms of unveiling the role of 5hmC; whether it serves either merely as an intermediate of DNA demethylation or as a stable epigenetic marker. 5-hydroxymethylcytosine (5hmC) is proved to be not merely serving as an intermediate of DNA demethylation, but also acts as a stable epigenetic marker. This review summarizes the current knowledge of the function of 5hmC in brain with the focus on the neuronal activity, neurodevelopment, aging, and neurological diseases. (C) 2014 Elsevier Inc. All rights reserved.
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