期刊
GENOMICS
卷 93, 期 3, 页码 235-242出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2008.10.006
关键词
Liver development; Microarray; Gene expression; Function; Transcriptional regulation
资金
- NHGRI NIH HHS [R01 HG001696-07, R01 HG001696-11, R01 HG001696] Funding Source: Medline
- NIGMS NIH HHS [R01 GM084198] Funding Source: Medline
The liver performs a number of essential functions for life. The development of such a Complex Organ relies on finely regulated gene expression profiles which change over time in the development and determine the phenotype and function of the liver. We used high-density oligonucleotide microarrays to study the gene expression and transcription regulation at 14 time points across the C57/B6 mouse liver development, which include E11.5 (embryonic day 11.5), E12.5, E13.5, E14.5, E15.5, E16.5, E17.5, E18.5, Day0 (the day of birth), Day3, Day7, Day14, Day21, and normal adult liver. With these data, we made a comprehensive analysis on gene expression patterns, functional preferences and transcriptional regulations during the liver development. A group of uncharacterized genes which might be involved in the fetal hematopoiesis were detected. (C) 2008 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据