期刊
GENOMICS
卷 93, 期 5, 页码 481-486出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ygeno.2009.01.001
关键词
Replication timing; alpha-globin gene domain; DNasel sensitivity; Chromatin domain
资金
- EcoNet collaborative grant
- Presidium of the Russian Academy of Sciences
- RFBR [08-04-00048-a, 08-04-91970]
- Association Francaise contre les Myopathies
- Fondation de France
- French Ministry of Foreign Affairs
- [PICS 3207]
The vertebrate alpha-globin gene domain is an open chromatin domain overlapping a neighboring house-keeping gene. The tissue-specific cluster of alpha-globin genes and the overlapping housekeeping gene share the same replication origin. We have studied the replication timing of chicken alpha-globin genes in cells of different lineages using the FISH-based approach and found that alpha-globin genes replicate early both in erythroid and in non-erythroid cells, i.e. regardless of their transcriptional activity. Early replication timing of chicken alpha-globin genes in cells of different lineages was in good correlation with the open chromatin configuration of the alpha-globin gene domain in both erythroid and non-erythroid cells. We propose that active transcription of the housekeeping gene overlapping the alpha-globin gene domain enables an access of Origin Recognition Complex (ORC) proteins to the replication origin resulting in early replication of alpha-globin genes even in non-erythroid cells. (c) 2009 Elsevier Inc. All rights reserved.
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