期刊
GENOME RESEARCH
卷 24, 期 3, 页码 390-400出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.163519.113
关键词
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资金
- Uehara Memorial Foundation
- Japan Society for the Promotion of Science
- EMBL Interdisciplinary Postdoc (EIPOD) fellowship under Marie Curie Actions COFUND
- European Molecular Biology Laboratory
- European Commission-FP7 [Health 223210/CISSTEM]
- Human Frontier Science Program [RGY0081/2008-C]
Long-range regulatory interactions play an important role in shaping gene-expression programs. However, the genomic features that organize these activities are still poorly characterized. We conducted a large operational analysis to chart the distribution of gene regulatory activities along the mouse genome, using hundreds of insertions of a regulatory sensor. We found that enhancers distribute their activities along broad regions and not in a gene-centric manner, defining large regulatory domains. Remarkably, these domains correlate strongly with the recently described TADs, which partition the genome into distinct self-interacting blocks. Different features, including specific repeats and CTCF-binding sites, correlate with the transition zones separating regulatory domains, and may help to further organize promiscuously distributed regulatory influences within large domains. These findings support a model of genomic organization where TADs confine regulatory activities to specific but large regulatory domains, contributing to the establishment of specific gene expression profiles.
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