期刊
GENOME RESEARCH
卷 23, 期 10, 页码 1663-1674出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.152538.112
关键词
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资金
- National Institutes of Health [K99GM100000]
- Howard Hughes Medical Institute
- Gordon and Betty Moore Foundation [GBMF3034]
- Mary K. Chapman Foundation
- National Science Foundation [MCB-0929402, MCB1122246]
- Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy [DE-FG02-08ER15309]
- United Soybean Board
- North Central Soybean Research Program
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1025752] Funding Source: National Science Foundation
Cytosine DNA methylation is one avenue for passing information through cell divisions. Here, we present epigenomic analyses of soybean recombinant inbred lines (RILs) and their parents. Identification of differentially methylated regions (DMRs) revealed that DMRs mostly cosegregated with the genotype from which they were derived, but examples of the uncoupling of genotype and epigenotype were identified. Linkage mapping of methylation states assessed from whole-genome bisulfite sequencing of 83 RILs uncovered widespread evidence for local methylQTL. This epigenomics approach provides a comprehensive study of the patterns and heritability of methylation variants in a complex genetic population over multiple generations, paving the way for understanding how methylation variants contribute to phenotypic variation.
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