4.6 Article

Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Compensates for Interleukin-6 in Initial B Cell Activation

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JOURNAL OF VIROLOGY
卷 90, 期 4, 页码 2150-2154

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AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02456-15

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  1. UNC CFAR [P30 AI50410]
  2. HHS | U.S. Public Health Service (USPHS) [CA109232 CA019014]

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Interleukin 6 (IL-6) is considered a proliferation and survival factor for B cells. To assess the role of IL-6 in Kaposi sarcoma-associated herpesvirus (KSHV) latency, KSHV latency locus-transgenic mice (referred to as latency mice) lacking IL-6 were evaluated. IL-6(-/-) latency mice had the same phenotypes as the latency mice, i.e., increased frequency of marginal zone B cells, hyperplasia, and hyperglobulinemia, indicating that the KSHV latency locus, which includes all viral microRNAs (miRNAs), can compensate for lack of IL-6 in premalignant B cell activation.

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