期刊
JOURNAL OF VIROLOGY
卷 90, 期 3, 页码 1682-1686出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02847-15
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- HHS\NIH\National Institute of Allergy and Infectious Diseases (NIAID) [AI-093198, HHSN27201100016C]
Newcastle disease virus (NDV) expressing HIV-1 BaL gp160 was evaluated either alone or with monomeric BaL gp120 and BaL SOSIP gp140 protein in a prime-boost combination in guinea pigs to enhance envelope (Env)-specific humoral and mucosal immune responses. We showed that a regimen consisting of an NDV prime followed by a protein boost elicited stronger serum and mucosal Th-1-biased IgG responses and neutralizing antibody responses than NDV-only immunizations. Additionally, these responses were higher after the gp120 than after the SOSIP gp140 protein boost.
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