期刊
GENOME BIOLOGY AND EVOLUTION
卷 6, 期 6, 页码 1387-1392出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evu113
关键词
pig; lincRNA; domestication
资金
- National 863 Program of China [2011AA100304-5]
- Ministry of Agriculture of China [2011ZX08009-003-006]
- National 973 Program of China [2013CB835203]
- National Natural Science Foundation of China [31061160189]
- Yunnan Provincial Science and Technology Department [2011AB008]
Thousands of long intergenic noncoding RNAs (lincRNAs) have been identified in the human and mouse genomes, some of which play important roles in fundamental biological processes. The pig is an important domesticated animal, however, pig lincRNAs remain poorly characterized and it is unknown if they were involved in the domestication of the pig. Here, we used available RNA-seq resources derived from 93 samples and expressed sequence tag data sets, and identified 6,621 lincRNA transcripts from 4,515 gene loci. Among the identified lincRNAs, some lincRNA genes exhibit synteny and sequence conservation, including linc-sscg2561, whose gene neighbor Dnmt3a is associated with emotional behaviors. Both linc-sscg2561 and Dnmt3a show differential expression in the frontal cortex between domesticated pigs and wild boars, suggesting a possible role in pig domestication. This study provides the first comprehensive genome-wide analysis of pig lincRNAs.
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