4.5 Article

Elucidating the Genotype-Phenotype Relationships and Network Perturbations of Human Shared and Specific Disease Genes from an Evolutionary Perspective

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Genetics & Heredity

A general framework for estimating the relative pathogenicity of human genetic variants

Martin Kircher et al.

NATURE GENETICS (2014)

Article Biochemistry & Molecular Biology

iPfam: a database of protein family and domain interactions found in the Protein Data Bank

Robert D. Finn et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

DrugBank 4.0: shedding new light on drug metabolism

Vivian Law et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

3did: a catalog of domain-based interactions of known three-dimensional structure

Roberto Mosca et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Multidisciplinary Sciences

Harnessing Gene Expression Networks to Prioritize Candidate Epileptic Encephalopathy Genes

Karen L. Oliver et al.

PLOS ONE (2014)

Article Biochemistry & Molecular Biology

Complex-forming proteins escape the robust regulations of miRNA in human

Jyotirmoy Das et al.

FEBS LETTERS (2013)

Article Evolutionary Biology

Evolutionary Rate Heterogeneity of Core and Attachment Proteins in Yeast Protein Complexes

Sandip Chakraborty et al.

GENOME BIOLOGY AND EVOLUTION (2013)

Article Evolutionary Biology

Evolutionary Survey of Druggable Protein Targets with Respect to Their Subcellular Localizations

Xiaotong Wang et al.

GENOME BIOLOGY AND EVOLUTION (2013)

Article Biochemical Research Methods

Global versus Local Hubs in Human Protein-Protein Interaction Network

Manjari Kiran et al.

JOURNAL OF PROTEOME RESEARCH (2013)

Article Biochemistry & Molecular Biology

Ensembl 2013

Paul Flicek et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Biochemical Research Methods

Target Essentiality and Centrality Characterize Drug Side Effects

Xiujuan Wang et al.

PLOS COMPUTATIONAL BIOLOGY (2013)

Article Biotechnology & Applied Microbiology

Biological function through network topology: a survey of the human diseasome

Vuk Janjic et al.

BRIEFINGS IN FUNCTIONAL GENOMICS (2012)

Article Biochemistry & Molecular Biology

A systematic characterization of genes underlying both complex and Mendelian diseases

Wenfei Jin et al.

HUMAN MOLECULAR GENETICS (2012)

Article Biochemistry & Molecular Biology

Novel insights through the integration of structural and functional genomics data with protein networks

Declan Clarke et al.

JOURNAL OF STRUCTURAL BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Independent Effects of Alternative Splicing and Structural Constraint on the Evolution of Mammalian Coding Exons

Feng-Chi Chen et al.

MOLECULAR BIOLOGY AND EVOLUTION (2012)

Article Biotechnology & Applied Microbiology

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

Xiujuan Wang et al.

NATURE BIOTECHNOLOGY (2012)

Article Biochemistry & Molecular Biology

SIFT web server: predicting effects of amino acid substitutions on proteins

Ngak-Leng Sim et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Multidisciplinary Sciences

Insights into the Evolutionary Features of Human Neurodegenerative Diseases

Arup Panda et al.

PLOS ONE (2012)

Article Biochemical Research Methods

When orthologs diverge between human and mouse

Walid H. Gharib et al.

BRIEFINGS IN BIOINFORMATICS (2011)

Article Genetics & Heredity

Molecular Evolution, Mutation Size and Gene Pleiotropy: A Geometric Reexamination

Pablo Razeto-Barry et al.

GENETICS (2011)

Article Evolutionary Biology

Substitution Patterns Are Under Different Influences in Primates and Rodents

Yves Clement et al.

GENOME BIOLOGY AND EVOLUTION (2011)

Article Biochemistry & Molecular Biology

The quantitative proteome of a human cell line

Martin Beck et al.

MOLECULAR SYSTEMS BIOLOGY (2011)

Review Genetics & Heredity

Network medicine: a network-based approach to human disease

Albert-Laszlo Barabasi et al.

NATURE REVIEWS GENETICS (2011)

Article Biochemistry & Molecular Biology

DIMA 3.0: Domain Interaction Map

Qibin Luo et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Evolutionary Biology

Expression breadth and expression abundance behave differently in correlations with evolutionary rates

Seung Gu Park et al.

BMC EVOLUTIONARY BIOLOGY (2010)

Article Mathematical & Computational Biology

Network properties of human disease genes with pleiotropic effects

Sreenivas Chavali et al.

BMC SYSTEMS BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Understanding the Effect of Secondary Structures and Aggregation on Human Protein Folding Class Evolution

Tina Begum et al.

JOURNAL OF MOLECULAR EVOLUTION (2010)

Article Biochemistry & Molecular Biology

Exploring the Differences in Evolutionary Rates between Monogenic and Polygenic Disease Genes in Human

Soumita Podder et al.

MOLECULAR BIOLOGY AND EVOLUTION (2010)

Article Biochemistry & Molecular Biology

CORUM: the comprehensive resource of mammalian protein complexes-2009

Andreas Ruepp et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Biochemical Research Methods

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

Eran Eden et al.

BMC BIOINFORMATICS (2009)

Article Evolutionary Biology

Similarly Strong Purifying Selection Acts on Human Disease Genes of All Evolutionary Ages

James J. Cai et al.

GENOME BIOLOGY AND EVOLUTION (2009)

Article Evolutionary Biology

Nonlinear Dynamics of Nonsynonymous (d(N)) and Synonymous (d(S)) Substitution Rates Affects Inference of Selection

Jochen B. W. Wolf et al.

GENOME BIOLOGY AND EVOLUTION (2009)

Article Biochemistry & Molecular Biology

Edgetic perturbation models of human inherited disorders

Quan Zhong et al.

MOLECULAR SYSTEMS BIOLOGY (2009)

Article Biochemistry & Molecular Biology

McKusick's Online Mendelian Inheritance in Man (OMIM®)

Joanna Amberger et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Biochemistry & Molecular Biology

Human Protein Reference Database-2009 update

T. S. Keshava Prasad et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

Bi-Directional SIFT Predicts a Subset of Activating Mutations

William Lee et al.

PLOS ONE (2009)

Article Multidisciplinary Sciences

Structural imperatives impose diverse evolutionary constraints on helical membrane proteins

Amit Oberai et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Genetics & Heredity

The Human Gene Mutation Database: 2008 update

Peter D. Stenson et al.

GENOME MEDICINE (2009)

Article Biochemical Research Methods

An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data

Daniel Ramskold et al.

PLOS COMPUTATIONAL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Topological properties of protein interaction networks from a structural perspective

Attila Gursoy et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2008)

Article Biochemistry & Molecular Biology

Natural selection on genes that underlie human disease susceptibility

Ran Blekhman et al.

CURRENT BIOLOGY (2008)

Article Multidisciplinary Sciences

Alternative isoform regulation in human tissue transcriptomes

Eric T. Wang et al.

NATURE (2008)

Article Multidisciplinary Sciences

A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes

Kasper Lage et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Null mutations in human and mouse orthologs frequently result in different phenotypes

Ben-Yang Liao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biotechnology & Applied Microbiology

Functional protein divergence in the evolution of Homo sapiens

Nuria Lopez-Bigas et al.

GENOME BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Recombination rates of genes expressed in human tissues

Mamoru Kato et al.

HUMAN MOLECULAR GENETICS (2008)

Article Multidisciplinary Sciences

A Structural Split in the Human Genome

Clara S. M. Tang et al.

PLOS ONE (2007)

Article Multidisciplinary Sciences

The human disease network

Kwang-Il Goh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Relating three-dimensional structures to protein networks provides evolutionary insights

Philip M. Kim et al.

SCIENCE (2006)

Article Genetics & Heredity

Toward a molecular understanding of pleiotropy

Xionglei He et al.

GENETICS (2006)

Article Biotechnology & Applied Microbiology

Differences in the evolutionary history of disease genes affected by dominant or recessive mutations

Simon J. Furney et al.

BMC GENOMICS (2006)

Review Genetics & Heredity

An integrated view of protein evolution

C Pál et al.

NATURE REVIEWS GENETICS (2006)

Article Biochemistry & Molecular Biology

Evolutionary conservation of expression profiles between human and mouse orthologous genes

BY Liao et al.

MOLECULAR BIOLOGY AND EVOLUTION (2006)

Article Biochemistry & Molecular Biology

A single determinant dominates the rate of yeast protein evolution

DA Drummond et al.

MOLECULAR BIOLOGY AND EVOLUTION (2006)

Article Biochemistry & Molecular Biology

Structural determinants of the rate of protein evolution in yeast

Jesse D. Bloom et al.

MOLECULAR BIOLOGY AND EVOLUTION (2006)

Review Multidisciplinary Sciences

A haplotype map of the human genome

D Altshuler et al.

NATURE (2005)

Letter Biochemistry & Molecular Biology

Comparative genomics of centrality and essentiality in three eukaryotic protein-interaction networks

MW Hahn et al.

MOLECULAR BIOLOGY AND EVOLUTION (2005)

Article Biochemistry & Molecular Biology

Mammalian housekeeping genes evolve more slowly than tissue-specific genes

LQ Zhang et al.

MOLECULAR BIOLOGY AND EVOLUTION (2004)

Article Biochemistry & Molecular Biology

Elevated rates of protein secretion, evolution, and disease among tissue-specific genes

EE Winter et al.

GENOME RESEARCH (2004)

Article Biochemistry & Molecular Biology

Genome-wide identification of genes likely to be involved in human genetic disease

N López-Bigas et al.

NUCLEIC ACIDS RESEARCH (2004)

Letter Genetics & Heredity

The Genetic Association Database

KG Becker et al.

NATURE GENETICS (2004)

Article Biotechnology & Applied Microbiology

Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomes

H Huang et al.

GENOME BIOLOGY (2004)

Article Genetics & Heredity

Human disease genes: patterns and predictions

NGC Smith et al.

Article Multidisciplinary Sciences

Evolutionary rate in the protein interaction network

HB Fraser et al.

SCIENCE (2002)

Article Biochemistry & Molecular Biology

Estimating synonymous and nonsynonymous substitution rates under realistic evolutionary models

ZH Yang et al.

MOLECULAR BIOLOGY AND EVOLUTION (2000)