期刊
GENOME BIOLOGY AND EVOLUTION
卷 5, 期 6, 页码 1142-1150出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evt079
关键词
telomeres; centromeres; G-quadruplexes; non-LTR retrotransposons
资金
- Ministerio de Ciencia e Innovacion [BES-2009-027909, CTQ2010-21567-C02-02]
- Fundacion Ramon Areces to the Centro de Biologia Molecular Severo Ochoa
- Ministerio de Economia y Competitividad [BFU2011-30295-C02-01]
The transition of an ancestral circular genome to multiple linear chromosomes was crucial for eukaryogenesis because it allowed rapid adaptive evolution through aneuploidy. Here, we propose that the ends of nascent linear chromosomes should have had a dual function in chromosome end protection (capping) and chromosome segregation to give rise to the proto-telomeres. Later on, proper centromeres evolved at subtelomeric regions. We also propose that both noncanonical structures based on guanine-guanine interactions and the end-protection proteins recruited by the emergent telomeric heterochromatin have been required for telomere maintenance through evolution. We further suggest that the origin of Drosophila telomeres may be reminiscent of how the first telomeres arose.
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