期刊
GENOME BIOLOGY AND EVOLUTION
卷 5, 期 10, 页码 1969-1977出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evt147
关键词
mitochondrial DNA; maternal inheritance; Drosophila melanogaster; Danio rerio; reactive oxygen species; aging
资金
- Leverhulme Trust [F/07 476/AQ]
- U.K. Natural Environment Research Council [NE/G005516/1]
- Consejo Nacional de Ciencia y Tecnologia [179835]
- NERC [NE/G005516/1] Funding Source: UKRI
- Natural Environment Research Council [NE/G005516/1] Funding Source: researchfish
Respiratory electron transport in mitochondria is coupled to ATP synthesis while generating mutagenic oxygen free radicals. Mitochondrial DNA mutation then accumulates with age, and may set a limit to the lifespan of individual, multicellular organisms. Why is this mutation not inherited? Here we demonstrate that female gametes-oocytes-have unusually small and simple mitochondria that are suppressed for DNA transcription, electron transport, and free radical production. By contrast, male gametes-sperm-and somatic cells of both sexes transcribe mitochondrial genes for respiratory electron carriers and produce oxygen free radicals. This germ-line division between mitochondria of sperm and egg is observed in both the vinegar fruitfly and the zebrafish-species spanning a major evolutionary divide within the animal kingdom. We interpret these findings as an evidence that oocyte mitochondria serve primarily as genetic templates, giving rise, irreversibly and in each new generation, to the familiar energy-transducing mitochondria of somatic cells and male gametes. Suppressed mitochondrial metabolism in the female germ line may therefore constitute a mechanism for increasing the fidelity of mitochondrial DNA inheritance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据