期刊
GENOME BIOLOGY AND EVOLUTION
卷 2, 期 -, 页码 39-43出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evp058
关键词
evolutionary rate; subcellular localization; gene essentiality; gene expression level; mammal; yeast
资金
- Taiwan National Health Research Institutes
- US National Institutes of Health
It is of fundamental importance to understand the determinants of the rate of protein evolution. Eukaryotic extracellular proteins are known to evolve faster than intracellular proteins. Although this rate difference appears to be due to the lower essentiality of extracellular proteins than intracellular proteins in yeast, we here show that, in mammals, the impact of extracellularity is independent from the impact of gene essentiality. Our partial correlation analysis indicated that the impact of extracellularity on mammalian protein evolutionary rate is also independent from those of tissue-specificity, expression level, gene compactness, and the number of protein-protein interactions and, surprisingly, is the strongest among all the factors we examined. Similar results were also found from principal component regression analysis. Our findings suggest that different rules govern the pace of protein sequence evolution in mammals and yeasts.
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