期刊
GENETICS IN MEDICINE
卷 11, 期 8, 页码 559-567出版社
NATURE PUBLISHING GROUP
DOI: 10.1097/GIM.0b013e3181b13a6c
关键词
behavioral sciences; epidemiologic methods; evidence-based medicine; genetics; genetic testing; genomics; medicine; public health
资金
- NCRR NIH HHS [M01 RR000533-360391, M01 RR000533] Funding Source: Medline
- NHGRI NIH HHS [R01 HG005092-01A1, R01 HG002213, R01 HG002213-01, R01 HG005092] Funding Source: Medline
- NIA NIH HHS [P30 AG013846-069001, K24 AG027841-01A1, P30 AG013846, K24 AG027841] Funding Source: Medline
The increasing availability of personal genomic tests has led to discussions about the validity and utility of such tests and the balance of benefits and harms. A multidisciplinary workshop was convened by the National Institutes of Health and the Centers for Disease Control and Prevention to review the scientific foundation for using personal genomics in risk assessment and disease prevention and to develop recommendations for targeted research. The clinical validity and utility of personal genomics is a moving target with rapidly developing discoveries but little translation research to close the gap between discoveries and health impact. Workshop participants made recommendations in five domains: (1) developing and applying scientific standards for assessing personal genomic tests; (2) developing and applying a multidisciplinary research agenda, including observational studies and clinical trials to fill knowledge gaps in clinical validity and utility; (3) enhancing credible knowledge synthesis and information dissemination to clinicians and consumers; (4) linking scientific findings to evidence-based recommendations for use of personal genomics; and (5) assessing how the concept of personal utility can affect health benefits, costs, and risks by developing appropriate metrics for evaluation. To fulfill the promise of personal genomics, a rigorous multidisciplinary research agenda is needed. Genet Med 2009:11(8):559-567.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据