期刊
GENETICS AND MOLECULAR RESEARCH
卷 10, 期 1, 页码 465-470出版社
FUNPEC-EDITORA
DOI: 10.4238/vol10-1gmr940
关键词
Endometriosis; Polymorphism and Infertility; Estrogen receptor
We examined the frequency of RsaI polymorphism of the ER beta gene in 54 patients diagnosed with endometriosis and 46 controls. Peripheral blood was collected from women undergoing laparoscopy with a confirmed diagnosis of endometriosis. Polymorphisms of the ER beta gene and p53 were assessed by PCR and analyzed on 2% agarose gel stained with ethidium bromide. The AG polymorphism genotype frequency in patients with endometriosis was 59.3%, with 40.7% GG. In the control group, the frequency of AG was 6.5%, with 93.5% GG. The frequency of heterozygous AG was nine times higher in patients with endometriosis than in the control group (P < 0.0001).
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