期刊
GENETICS AND MOLECULAR BIOLOGY
卷 32, 期 2, 页码 212-219出版社
SOC BRASIL GENETICA
DOI: 10.1590/S1415-47572009000200002
关键词
HLA-DRB1; polymorphism; Amerindians; biological affinities
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnica (CONICET [PIP 5393]
- Universidad de Buenos Aires (UBACyT) [F044]
The major histocompatibility complex (MHC) is one of the biological systems of major polymorphisms. The study of HLA class II variability has allowed the identification of several alleles that are characteristic to Amerindian populations, and it is an excellent tool to define the relations and biological affinities among them. In this work, we analyzed the allelic distribution of the HLA-DRB1 class II locus in four Amerindian populations: Mapuche (n=34) and Tehuelche (n=23) from the Patagonian region of Argentina, and Wichi SV (n=24) and Lengua (n=17) from the Argentinean and Paraguayan Chaco regions, respectively. In all of these groups, relatively high frequencies of Amerindian HLA-DRB1 alleles were observed (DRB1*0403, DRB1*0407, DRB1*0411, DRB1*0417, DRB1*0802, DRB1*0901, DRB1*1402, DRB1*1406 and DRB1*1602). However, we also detected the presence of non-Amerindian variants in Mapuche (35%) and Tehuelche (22%). We compared our data with those obtained in six indigenous groups of the Argentinean Chaco region and in a sample from Buenos Aires City. The genetic distance dendrogram showed a clear-cut division between the Patagonian and Chaco populations, which formed two different clusters. In spite of their linguistic differences, it can be inferred that the biological affinities observed are in concordance with the geographic distributions and interethnic relations established among the groups studied.
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