期刊
GENETICS AND MOLECULAR BIOLOGY
卷 32, 期 1, 页码 12-19出版社
SOC BRASIL GENETICA
DOI: 10.1590/S1415-47572009005000011
关键词
CCR5; Brazilian; Amerindian; HIV; polymorphism
资金
- Brazilian National Counsel of Technological and Scientific Development (Conselho Nacional de Desenvolvimento Cientfico e Tecnologico - CNPq)
The CC chemokine receptor 5 (CCR5) molecule is an important co-receptor for HIV. The effect of the CCR5*D32 allele in susceptibility to HIV infection and AIDS disease is well known. Other alleles than CCR5*D32 have not been analysed before, neither in Amerindians nor in the majority of the populations all over the world. We investigated the distribution of the CCR5 coding region alleles in South Brazil and noticed a high CCR5*D32 frequency in the Euro- Brazilian population of the Parana State (9.3%), which is the highest thus far reported for Latin America. The D32 frequency is even higher among the Euro- Brazilian Mennonites (14.2%). This allele is uncommon in Afro-Brazilians (2.0%), rare in the Guarani Amerindians (0.4%) and absent in the Kaingang Amerindians and the Oriental-Brazilians. R223Q is common in the Oriental-Brazilians (7.7%) and R60S in the Afro-Brazilians (5.0%). A29S and L55Q present an impaired response to beta-chemokines and occurred in Afro- and Euro- Brazilians with cumulative frequencies of 4.4% and 2.7%, respectively. Two new non-synonymous alleles were found in Amerindians: C323F (g.3729G> T) in Guarani (1.4%) and Y68C (g. 2964A > G) in Kaingang (10.3%). The functional characteristics of these alleles should be defined and considered in epidemiological investigations about HIV-1 infection and AIDS incidence in Amerindian populations.
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