期刊
GENETICS
卷 194, 期 4, 页码 1029-+出版社
GENETICS SOC AM
DOI: 10.1534/genetics.113.152710
关键词
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资金
- University of Wisconsin
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health [R00 NS072252, R00 NS060985]
We have adapted a bacterial CRISPR RNA/Cas9 system to precisely engineer the Drosophila genome and report that Cas9-mediated genomic modifications are efficiently transmitted through the germline. This RNA-guided Cas9 system can be rapidly programmed to generate targeted alleles for probing gene function in Drosophila.
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