期刊
GENETICS
卷 195, 期 3, 页码 1173-1176出版社
GENETICS SOC AM
DOI: 10.1534/genetics.113.155754
关键词
genome editing; CRISPR; Cas9; homologous recombination; gene conversion; Caenorhabditis elegans
资金
- National Institutes of Health Office of Research Infrastructure Programs [P40 OD010440]
- Novartis Research Foundation through FMI
- Swiss National Science Foundation [SNF 31003A_143313]
- European Union Seventh Framework Program (European Research Council grant) [241985]
- Swiss National Science Foundation (SNF) [31003A_143313] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [241985] Funding Source: European Research Council (ERC)
We have achieved targeted heritable genome modification in Caenorhabditis elegans by injecting mRNA of the nuclease Cas9 and Cas9 guide RNAs. This system rapidly creates precise genomic changes, including knockouts and transgene-instructed gene conversion.
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