期刊
GENETICS
卷 189, 期 4, 页码 1177-1201出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.111.133363
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资金
- Cantons of Basel and Geneva, SystemsX.ch
- Frontiers in Genetics and Chemical Biology National Centers for Competence in Research
- European Research Council
- Louis-Jeantet and Leenaards Foundations
- Swiss National Science Foundation
TOR (Target Of Rapamycin) is a highly conserved protein kinase that is important in both fundamental and clinical biology. In fundamental biology, TOR is a nutrient-sensitive, central controller of cell growth and aging. In clinical biology, TOR is implicated in many diseases and is the target of the drug rapamycin used in three different therapeutic areas. The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function. Here we review the TOR signaling network in S. cerevisiae.
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