期刊
GENETICS
卷 184, 期 4, 页码 1153-U464出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.109.112920
关键词
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资金
- Biotechnology and Biological Sciences Research Council (BBSRC)
- University of British Columbia
- Natural Sciences and Engineering Research Council of Canada
- e-Science Data, Information and Knowledge Transformation initiative
- BBSRC [BB/D015480/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D015480/1] Funding Source: researchfish
Although the evolution of recombination is still a major problem in evolutionary genetics, recent theoretical studies have shown that recombination can evolve by breaking down interference (Hill-Robertson effects) among multiple loci. This leads to selection on a recombination modifier in a population subject to recurrent deleterious mutation. Here, we use computer simulations to investigate the evolution of a recombination modifier under three different scenarios of recurrent mutation in a finite population: (1) mutations are deleterious only, (2) mutations are advantageous only, and (3) there is a mixture of deleterious and advantageous mutations. We also investigate how linkage disequilibrium, the strength of selection acting on a modifier, and effective population size change under the different scenarios. We observe that adding even a small number of advantageous mutations increases the fixation rate of modifiers that increase recombination, especially if the effects of deleterious mutations are weak. However, the strength of selection on a modifier is less than the summed strengths had there been deleterious mutations only and advantageous mutations only.
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