4.4 Article

Analysis of Ipl1-Mediated Phosphorylation of the Ndc80 Kinetochore Protein in Saccharomyces cerevisiae

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GENETICS
卷 183, 期 4, 页码 1591-1595

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GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.109.109041

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  1. National Institutes of Health [GM064386]
  2. National Institute of General Medical Sciences [PM50 GM076547]
  3. Leukemia and Lymphoma Society

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Phosphorylation of the Ndc80 kinetochore protein by the Ipl1/Aurora B kinase reduces its microtubule binding activity in vitro. We found that kinetochore-bound Ndc80 is phosphorylated on Ipl1 sites in vivo, but this phosphorylation is not essential. Instead, we show that additional Ipl1 targets contribute to segregation and the spindle checkpoint.

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