期刊
GENETICS
卷 182, 期 4, 页码 1387-1389出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.109.101436
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资金
- NIA NIH HHS [T32 AG000139] Funding Source: Medline
- NICHD NIH HHS [R03 HD050374] Funding Source: Medline
The middle-class neighborhood is a breeding design intended to allow new mutations accumulate by lessening the effects of purifying selection through the elimination of among-line fitness variation. We show that this design effectively applies soft selection to the experimental population, potentially causing biased estimates of mutational effects if social effects contribute to fitness.
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