期刊
GENETICS
卷 179, 期 4, 页码 2173-2182出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.108.088559
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资金
- NHGRI NIH HHS [P50 HG-02568, P50 HG002568] Funding Source: Medline
- NIGMS NIH HHS [T32 GM-07270, T32 GM007270, R01 GM071854, R01 GM-071854] Funding Source: Medline
To identify the processes shaping vertebrate sex chromosomes during the early stages of their evolution, it is necessary to study systems in which genetic sex determination was recently acquired. Previous cytogenetic studies suggested that threespine stickleback fish (Gasterosteus aculeatus) do not have a heteromorphic sex chromosome pair, although recent genetics studies found evidence of an XY genetic sex-determination system. Using flourescence in situ hybridization (FISH), we report that the threespine stickleback Y chromosome is heteromorphic and has suffered both inversions and deletion. Using the FISH data, we reconstruct the rearrangements that have led to the current physical state of the threespine stickleback Y chromosome. These data demonstrate that the threespine Y is more degenerate than previously thought, suggesting that the process of sex chromosome evolution can occur rapidly following acquisition of a sex-determining region.
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