期刊
GENETICS
卷 180, 期 1, 页码 619-628出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.108.090407
关键词
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资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [C06RR013556, P51RR013986, C06RR015456, C06RR017515] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL028972] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R21DE016408, R01DE016692] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH059490, R37MH059490] Funding Source: NIH RePORTER
- NCRR NIH HHS [C06 RR15456, C06 RR015456, C06 RR017515, P51 RR13986, C06 RR013556, P51 RR013986] Funding Source: Medline
- NHLBI NIH HHS [P01 HL028972, P01HL28972] Funding Source: Medline
- NIDCR NIH HHS [R21 DE016408, DE016692, R01 DE016692, DE016408] Funding Source: Medline
- NIMH NIH HHS [MH059490, R37 MH059490, R01 MH059490] Funding Source: Medline
Numerous studies have detected significant contributions of genes to variation in development, size and shape of craniofacial traits in a number of vertebrate taxa. This study examines 43 quantitative traits derived from lateral cephalographs of 830 baboons (papia hamadryas) from the pedigreed population housed at the Southwest National Primate Research Center. Quantitative genetic analyses were conducted using the SOLAR analytic platform, a maximum-likelihood variance components method that incorporates all familial information for parameter estimation. Heritability estimates were significant and of moderate to high magnitude for all craniofacial traits. Additionally, 14 significant quantitative trait loci (QTL) were identified for 12 traits from the three developmental components (basicranium, splanchnocranium, and neurocranium) of the craniofacial complex. These QTL wre found on baboon chromosomes (and human orthologs) PHA1 (HSA1), PHA 2 (HAS3), PHA4 (HSA6), PHA11 (HSA12), PHA13 (HSA2), PHA16 (HSA17), AND PHA17 (HSA13) (PHA, P. hamadrtas, HSA, Homo sapiens). This study of the genetic architecture of the craniofacial complex in baboons provides the groundwork needed to establish the baboon as an animal model for the study of genetic and nongenetic influences on craniofacial variation.
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