期刊
GENETICS
卷 180, 期 3, 页码 1559-1566出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.108.090597
关键词
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资金
- Ministerio de Ciencia e Innovacion [CGL2008-02343/BOS]
It has been widely appreciated that natural selection opposes the progress of inbreeding in small populations, thus limiting the actual inbreeding depression for fitness traits. However, no method to account for the consequences of this process has been given so far. I give a simple and intuitive method to predict inbreeding depression, taking into account the increase in selection efficiency against recessive alleles during inbreeding. It is based oil the use of a purged inbreeding coefficient g(t) that accounts for the reduction of the probability of the deleterious homozygotes caused by the excess d of detrimental effect for deleterious alleles in the homozygous condition over its additive expectation. It is shown that the effect of purging call be important even for relatively small populations. For between-loci variable deleterious effects, accurate predictions call be obtained using the effective homozygous deleterious excess d(e), which call be estimated experimentally and is robust against variation of the ancestral effective population size. The method can be extended to any trait and it is used to predict the evolution of the mean viability or fecundity in a conservation program with equal or random family contributions.
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