期刊
GENETICS
卷 178, 期 4, 页码 2123-2132出版社
GENETICS
DOI: 10.1534/genetics.107.084624
关键词
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资金
- NIGMS NIH HHS [3R01GM075091-02S1, R01 GM075091] Funding Source: Medline
- Wellcome Trust [076113] Funding Source: Medline
I present a new approach for calculating probabilities of identity by descent for pairs of haplotypes. The approach is based on a joint hidden Markov model for haplotype frequencies and identity by descent (IBD). This model allows for linkage disequilibrium, and the method can be applied to very dense marker data. The method has high power for detecting IBD tracts of genetic length of 1 cM, with the use of sufficiently dense markers. This enables detection of pairwise IBD between haplotypes from individuals whose most recent common ancestor lived up to 50 generations ago.
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