期刊
GENETICS
卷 178, 期 1, 页码 477-487出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.107.083196
关键词
-
资金
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002942] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [K99GM080099] Funding Source: NIH RePORTER
- NHGRI NIH HHS [R01-HG002942, R01 HG002942] Funding Source: Medline
- NIGMS NIH HHS [1K99-GM080099, K99 GM080099] Funding Source: Medline
DNA sequence Surveys in yeast and humans Suggest that. the forces shaping telomeric polymorphism and divergence are distinctly more dynamic than those in the euchromatic, gene-rich regions of the chromosomes. However, the generality of this pattern across outbreeding, multicellular eukaryotes has not been determined. To characterize the structure and evolution of Drosophila telomeres, we collected and analyzed molecular population genetics data from the X chromosome subtelomere in 58 lines of North American Drosophila)hila melanogaster and 29 lines of African D. melanogaster We found that Drosophila subtelomeres exhibit high levels of both structural and substitutional polymorphism relative to linked euchromatic regions. We also observed strikingly different patterns of variation in the North American and African samples. Moreover, Our analyses of the polymorphism data identify a localized hotspot of recombination it) the most-distal portion of the X subtelomere. While the levels of polymorphism decline sharply and in parallel with rates of crossing over per physical length over the distal first euchromatic megabase pairs of the X chromosome, Our data Suggest that they rise again sharply in the subtelomeric region (approximate to 80 kbp). These patterns of historical recombination and geographic differentiation indicate that, similar to yeast and humans, Drosophila subtelomeric DNA is evolving very differently from euchromatic DNA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据