期刊
GENETICS
卷 179, 期 1, 页码 527-537出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/genetics.107.081497
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The model of genetic hitchhiking predicts a reduction in sequence diversity at a neutral locus closely linked to a beneficial allele. In addition, it has been shown that the same process results in a specific pattern of correlations (linkage disequilibrium) between neutral polymorphisms along the chromosome at the time of fixation of the beneficial allele. During the hitchhiking event, linkage disequilibrium on either side of the beneficial allele is built Lip whereas it is destroyed across the selected site. We derive explicit formulas for the expectation of the covariance measure D and standardized linkage disequilibrium sigma(2)(D) between a pair of polymorphic sites. For our analysis we use the approximation of a star-like genealogy at the selected site. The resulting expressions are approximately correct in the limit of large selection Coefficients. Using Simulations we show that the resulting pattern of linkage disequilibrium is quickly-i.e., in <0.1N generations-destroyed after the fixation of the beneficial allele for moderately, distant neutral loci, where N is the diploid population size.
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