期刊
JOURNAL OF VIRAL HEPATITIS
卷 23, 期 1, 页码 62-64出版社
WILEY
DOI: 10.1111/jvh.12446
关键词
aspirin; claudin-1; hepatitis C virus entry
资金
- National Science and Technology Major Project of China [2013ZX10004-601]
- National Natural Science Foundation of China [81271832, 81471955]
- Fundamental Research Funds for the Central Universities
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13007]
Aspirin has previously been reported to inhibit hepatitis C virus (HCV) replication. The aim of this study was to investigate whether aspirin is involved in blocking HCV entry. We found that aspirin inhibits the entry of HCVpp and infectious HCV. The level of claudin-1, an HCV receptor, is reduced by aspirin. Our results extend the anti-HCV effect of aspirin to the HCV entry step and further reinforce the anti-HCV role of aspirin.
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