期刊
GENESIS
卷 52, 期 8, 页码 738-751出版社
WILEY
DOI: 10.1002/dvg.22789
关键词
germ cell migration; spermatogenesis; mitochondria; autophagy; Trl mutation
资金
- Russian Foundation for Basic Research [12-04-31804 mol a, 13-04-01013_a, 14-0400929]
The Drosophila Trithorax-like (Trl) gene encodes a GAGA factor which regulates a number of developmentally important genes. In this study, we identify a new function for Drosophila GAGA factor in male germ cell development. Trl mutants carrying strong hypomorphic alleles display loss of primordial germ cells during their migration in embryogenesis and severe disruption in mitochondria structure during early spermatogenesis. The mutation resulted in small testes formation, a deficit of germ cells, abnormal mitochondrial morphogenesis, spermatocyte death through autophagy, and partial or complete male sterility. Pleiotropic mutation effects can be explained by the misexpression of GAGA factor target genes, the products of which are required for germ cell progression into mature sperm. (C) 2014 Wiley Periodicals, Inc.
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