期刊
GENESIS
卷 49, 期 8, 页码 689-695出版社
WILEY
DOI: 10.1002/dvg.20741
关键词
Stella; Cre-loxP recombination; knock-in
资金
- Wellcome Trust
- China Scholarship Council
Cre-loxP recombination is widely used for genetic manipulation of the mouse genome. Here, we report generation and characterization of a new Cre line, Stella-Cre, where Cre expression cassette was targeted to the 3' UTR of the Stella locus. Stella is specifically expressed in preimplantation embryos and in the germline. Cre-loxP recombination efficiency in Stella-Cre mice was investigated at several genomic loci including Rosa26, Jak2, and Npm1. At all the loci examined, we observed 100% Cre-loxP recombination efficiency in the embryos and in the germline. Thus, Stella-Cre mice serve as a very efficient deleter line. genesis 49:689-695, 2011. (C) 2011 Wiley-Liss, Inc.
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