期刊
GENES TO CELLS
卷 16, 期 6, 页码 617-624出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2443.2011.01519.x
关键词
-
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [21247003]
- Grants-in-Aid for Scientific Research [21247003] Funding Source: KAKEN
The genome is composed not only of genes but also of several noncoding functional elements (NOCs/ncFE, here I use NOCs), such as transcriptional promoters, enhancers, replication origins, centromeres and telomeres. rDNA has both gene and NOC characteristics. Thus, the rDNA encodes ribosomal RNAs, components of the ribosomes, that account for approximately 80% of the total RNA in a cell. However, rDNA may also act as a NOC with respect to cellular senescence by limiting the number of times a cell can divide. Here, I discuss how rDNA might function as a NOC to influence life span in a manner analogous to telomeres.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据