期刊
GENES CHROMOSOMES & CANCER
卷 51, 期 5, 页码 480-489出版社
WILEY-BLACKWELL
DOI: 10.1002/gcc.21935
关键词
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资金
- National Institutes of Health [CA43460, CA573445, CA62924, CA121113]
- Swedish Cancer Foundation
- D.K. Ludwig Fund for Cancer Research
Exome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF-KB, and PIK3CA pathways in breast cancer development, and point to novel processes that likely are involved. (C) 2012 Wiley Periodicals, Inc.
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