期刊
GENES CHROMOSOMES & CANCER
卷 52, 期 2, 页码 150-155出版社
WILEY
DOI: 10.1002/gcc.22014
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资金
- Deutsche Krebshilfe [70-3173-Tr3]
- Kinderkrebsinitiative Buchholz/Holm-Seppensen
- Medizinausschuss Schleswig-Holstein
- Alexander von Humboldt Foundation
- Basque Government through the grant Ayuda del programa de perfeccionamiento postdoctoral en el extranjero del Departamento de Educacion, Universidades e Investigacion del Gobierno Vasco''
Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B-cell-derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we performed array-comparative genomic hybridization and molecular inversion probe microarray analyses on DNA from 12 formalin-fixed paraffin-embedded and two fresh-frozen IRF4 translocation-positive lymphomas, which together with the previously published data on nine cases allowed the extension of copy number analyses to a total of 23 of these lymphomas. All except one case carried chromosomal imbalances, most frequently gains in Xq28, 11q22.3-qter, and 7q32.1-qter and losses in 6q13-16.1, 15q14-22.31, and 17p. No recurrent copy-neutral losses of heterozygosity were observed. TP53 point mutations were detected in three of six cases with loss of 17p. Overall this study unravels a recurrent pattern of secondary genetic alterations in IRF4 translocation-positive lymphomas. (c) 2012 Wiley Periodicals, Inc.
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