期刊
GENES BRAIN AND BEHAVIOR
卷 12, 期 1, 页码 39-46出版社
WILEY
DOI: 10.1111/gbb.12013
关键词
5-HT2A; addiction; case-control association study; cocaine dependence; dopamine; genetics; HTR2A; neurotransmission; neurotrophic factors; serotonin
资金
- Plan Nacional sobre Drogas, Ministerio de Sanidad y Politica Social, Spain [2009/022]
- Ministerio de Economia y Competitividad, Spain [SAF2012-33484]
- Instituto de Salud Carlos III-FIS [PI051982]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca-AGAUR [2009SGR00971]
- Department of Health of the Government of Catalonia (Generalitat de Catalunya)
- Instituto de Salud Carlos III
- CIBER-ER
Cocaine dependence is a neuropsychiatric disorder in which both environmental and genetic factors are involved. Several processes, that include reward and neuroadaptations, mediate the transition from use to dependence. In this regard, dopamine and serotonin neurotransmission systems are clearly involved in reward and other cocaine-related effects, whereas neurotrophic factors may be responsible for neuroadaptations associated with cocaine dependence. We examined the contribution to cocaine dependence of 37 genes related to the dopaminergic and serotoninergic systems, neurotrophic factors and their receptors through a casecontrol association study with 319 single nucleotide polymorphisms selected according to genetic coverage criteria in 432 cocaine-dependent patients and 482 sex-matched unrelated controls. Single marker analyses provided evidence for association of the serotonin receptor HTR2A with cocaine dependence [rs6561333; nominal P-value adjusted for age?=?1.9e-04, odds ratio?=?1.72 (1.292.30)]. When patients were subdivided according to the presence or absence of psychotic symptoms, we confirmed the association between cocaine dependence and HTR2A in both subgroups of patients. Our data show additional evidence for the involvement of the serotoninergic system in the genetic susceptibility to cocaine dependence.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据