期刊
GENES AND IMMUNITY
卷 13, 期 4, 页码 346-350出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/gene.2011.85
关键词
IL-17; ROR gamma t; autoimmunity; gene regulation; T cells
资金
- National Institute of Health [R01 AI85567, R01 AI49954]
- Deutsche Forschungsgemeinschaft [RA1927/1-1]
T helper (Th)17 cells constitute a distinct subset of CD4(+) helper T cells that is mainly characterized by abundant interleukin (IL)-17 production and is involved in the host defence against bacteria and fungi as well as in the pathogenesis of autoimmune diseases. The retinoic orphan receptor (ROR)gamma t directs the transcriptional activation of the IL17 gene. Here, we report the presence of a novel ROR gamma t isoform, ROR gamma t-Delta(5-8), which lacks the hinge-encoding exons 5-8 and represses potently IL17 and IL21 gene transcription. It thereby reduces the expression of multiple Th17-assigned cytokines. We propose that ROR gamma t-Delta(5-8) acts as a dominant-negative regulator of ROR gamma t-mediated gene regulation and the balance between the full-length ROR gamma t and the novel repressor isoform may arbitrate IL-17 production in human T cells.
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