期刊
GENES AND IMMUNITY
卷 11, 期 2, 页码 155-160出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/gene.2009.71
关键词
copy number variation (CNV); FCGR3B; CCL3L1; systemic lupus erythematosus; Sjogren's syndrome
资金
- Voelcker Fund Scholar Award
- Max and Minnie Tomerlin Voelcker Fund
- Elizabeth Glaser Scientist Award
- Burroughs Wellcome Clinical Scientist Award in Translational Research
- Doris Duke Distinguished Clinical Scientist Award
- Rosario University, Bogota, Colombia
Copy number variation (CNV) in the human genome is an important determinant of susceptibility to autoimmune diseases. Many autoimmune diseases share similar clinical and pathogenic features. Thus, CNVs of genes involved in immunity may serve as shared determinants of multiple autoimmune diseases. Here, we determined the association between CNV in the gene encoding FCGR3B with the risk of developing autoimmune diseases and whether the observed associations are modified by the CNV in CCL3L1 (CC chemokine ligand 3-like 1), a gene encoding a potent chemokine. In a cross-sectional study of 774 subjects, we estimated FCGR3B and CCL3L1 gene copy number in 146, 158 and 61 subjects with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and primary Sjogren's syndrome (SS), respectively, and 409 healthy controls. The median gene dose of FCGR3B in the study population was two. FCGR3B copy number < or >2 was associated with an increased risk of SLE and primary SS but not RA. This association was mostly evident in subjects who also had two copies of CCL3L1. Thus, our data suggest that epistatic interactions between CNV of FCGR3B and CCL3L1, two immune response genes, may influence phenotypically related autoimmune diseases. Genes and Immunity (2010) 11, 155-160; doi:10.1038/gene.2009.71; published online 10 September 2009
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