期刊
GENES & GENETIC SYSTEMS
卷 89, 期 4, 页码 151-157出版社
GENETICS SOC JAPAN
DOI: 10.1266/ggs.89.151
关键词
epigenetic regulation; gene silencing; heterochromatin; X chromosome; Xist RNA
资金
- Grants-in-Aid for Scientific Research [26113714, 26116515] Funding Source: KAKEN
X chromosome inactivation (X-inactivation) is triggered by X-linked noncoding Xist RNA, which is expressed asymmetrically from one of the two X chromosomes in females and coats it in cis to induce chromosome-wide silencing. Xist RNA is thought to play a role as a platform in recruiting proteins involved in gene silencing and heterochromatinization, which mediate serial changes in epigenetic modification of the chromatin. During the last two decades, many proteins have been shown to be enriched on the inactivated X chromosome in mouse and human. Although the biological significance of most of them for X-inactivation has not been fully established, extensive studies of these proteins should provide a better understanding of the molecular basis of how X-inactivation mediated by Xist RNA is regulated. Here, we review the potential roles of some of these proteins in the stepwise process of Xist RNA-mediated chromosome silencing.
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