期刊
GENES & DEVELOPMENT
卷 28, 期 12, 页码 1272-1277出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.242271.114
关键词
transcription regulator; molecular evolution; Candida albicans; gene regulation; gene duplication; regulatory networks
资金
- American Heart Association
- University of California at San Francisco's Program for Breakthrough Biomedical Research (PBBR)
- US National Institute of General Medical Sciences [5K99GM099848]
- US National Institute of Allergy and Infectious Diseases [RO1 AI049187]
The duplication of transcription regulators can elicit major regulatory network rearrangements over evolutionary timescales. However, few examples of duplications resulting in gene network expansions are understood in molecular detail. Here we show that four Candida albicans transcription regulators that arose by successive duplications have differentiated from one another by acquiring different intrinsic DNA-binding specificities, different preferences for half-site spacing, and different associations with cofactors. The combination of these three mechanisms resulted in each of the four regulators controlling a distinct set of target genes, which likely contributed to the adaption of this fungus to its human host. Our results illustrate how successive duplications and diversification of an ancestral transcription regulator can underlie major changes in an organism's regulatory circuitry.
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