期刊
GENES & DEVELOPMENT
卷 28, 期 5, 页码 432-437出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.233676.113
关键词
Hippo signaling; YAP; differentiation; mammary gland; proliferation; tumorigenesis
资金
- National Institutes of Health [R01 CA113795, P50 CA088843]
- Flight Attendant Medical Research Institute
- American Cancer Society [RSG-12-141-01-CSM]
- Breast Cancer Research Post-doctoral Fellowship from the Department of Defense [BC093902]
Despite recent progress, the physiological role of Hippo signaling in mammary gland development and tumorigenesis remains poorly understood. Here we show that the Hippo pathway is functionally dispensable in virgin mammary glands but specifically required during pregnancy. In contrast to many other tissues, hyperactivation of YAP in mammary epithelia does not induce hyperplasia but leads to defects in terminal differentiation. Interestingly, loss of YAP causes no obvious defects in virgin mammary glands but potently suppresses oncogeneinduced mammary tumors. The selective requirement for YAP in oncogenic growth highlights the potential of YAP inhibitors as molecular targeted therapies against breast cancers.
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