期刊
GENES & DEVELOPMENT
卷 28, 期 16, 页码 1752-1757出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.245233.114
关键词
small intestinal stem cell; transplantation; stem cell niche; Paneth cell; regenerative medicine
资金
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) KAKENHI [24112508]
- Japan Society for the Promotion of Science (JSPS) KAKENHI [25670106, 24390186, 22229005]
- Japan Science and Technology Agency
- Ministry of Health, Labor, and Welfare of Japan
- Grants-in-Aid for Scientific Research [24590936, 22229005, 25670106, 26112705, 24112508, 24390186] Funding Source: KAKEN
To develop stem cell therapy for small intestinal (SI) diseases, it is essential to determine whether SI stem cells in culture retain their tissue regeneration capabilities. By using a heterotopic transplantation approach, we show that cultured murine SI epithelial organoids are able to reconstitute self-renewing epithelia in the colon. When stably integrated, the SI-derived grafts show many features unique only to the SI but distinct from the colonic epithelium. Our study provides evidence that cultured adult SI stem cells could be a source for cell therapy of intestinal diseases, maintaining their identity along the gastrointestinal tract through an epithelium-intrinsic mechanism.
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