期刊
GENES & DEVELOPMENT
卷 28, 期 15, 页码 1635-1640出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.245993.114
关键词
allelic heterogeneity; FLOWERING LOCUS C; noncoding polymorphism; vernalization; adaptation
资金
- UK Biotechnology and Biological Sciences Research Council (BBSRC) grant [BB/I007857/1]
- Institute Strategic Programme grant [BB/J004588/1]
- European Research Council Advanced Investigator grant [233039 ENVGENE]
- National Science Foundation Frontiers in Integrative Biological Research grant [NSF EF-0425759]
- BBSRC [BB/E009662/1, BBS/E/J/000CA344, BBS/E/T/000PR6193, BB/I007857/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/T/000PR6193, BBS/E/J/000CA344, BB/E009662/1, BB/I007857/1] Funding Source: researchfish
- Direct For Biological Sciences [1447203] Funding Source: National Science Foundation
- Division Of Environmental Biology [1447203] Funding Source: National Science Foundation
Relating molecular variation to phenotypic diversity is a central goal in evolutionary biology. In Arabidopsis thaliana, FLOWERING LOCUS C (FLC) is a major determinant of variation in vernalization-the acceleration of flowering by prolonged cold. Here, through analysis of 1307 A. thaliana accessions, we identify five predominant FLC haplotypes defined by noncoding sequence variation. Genetic and transgenic experiments show that they are functionally distinct, varying in FLC expression level and rate of epigenetic silencing. Allelic heterogeneity at this single locus accounts for a large proportion of natural variation in vernalization that contributes to adaptation of A. thaliana.
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