期刊
GENES & DEVELOPMENT
卷 27, 期 20, 页码 2192-2206出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.225334.113
关键词
epithelial-mesenchymal transition (EMT); mesenchymal-epithelial transition (MET); carcinoma metastasis; extravasation; intravasation; invasion; tumor dormancy
资金
- National Institutes of Health [1DP2OD002420]
- National Cancer Institute [1RO1CA168689]
- American Cancer Society [RSG-09-282-01-CSM]
- Hartwell Foundation
- DOD Breast Cancer Program [W81XWH-13-1-0132]
- NIH [T32CA121938]
- California Breast Cancer Program postdoctoral fellowship [16FB-0009]
Tumor metastasis is a multistep process by which tumor cells disseminate from their primary site and form secondary tumors at a distant site. Metastasis occurs through a series of steps: local invasion, intravasation, transport, extravasation, and colonization. A developmental program termed epithelial-mesenchymal transition (EMT) has been shown to play a critical role in promoting metastasis in epithelium-derived carcinoma. Recent experimental and clinical studies have improved our knowledge of this dynamic program and implicated EMT and its reverse program, mesenchymal-epithelial transition (MET), in the metastatic process. Here, we review the functional requirement of EMT and/or MET during the individual steps of tumor metastasis and discuss the potential of targeting this program when treating metastatic diseases.
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